The Merbein Parish is a member of the Sunraysia Regional Cluster. Since January 1997, the parish has been without a resident priest. Sr. Marion McDonald was appointed Parish Leader, until her retirement in May 2017. Fr Matthew Thomas is now the Parish priest of the OLSH Parish. The Sunday Mass and weekday Mass are conducted by the Mildura priests. Various parish groups look after the day to day running of the parish and organising the Sacramental preparation of the parishioners.